Currently, healthcare professionals advise it is safe to drink grapefruit juice and eat grapefruit if you're taking other types of statins. Calcium channel blockers are medicines that relax the muscles that make up the walls of your arteries. They're used as part of the treatment of conditions such as high blood pressure hypertension and coronary heart disease. Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood.
If you're taking any of the medicines below, seek advice from your pharmacist or doctor if you wish to include grapefruit or grapefruit juice in your diet. Grapefruit juice does not affect diltiazem.
Anticoagulants are medicines that help to prevent blood clots. They're given to people at high risk of getting clots, to reduce their chances of serious conditions such as strokes and heart attacks. Do not drink grapefruit juice if you're taking warfarin. It can increase the effect of warfarin on your blood, making you bleed more easily.
It's safer to drink grapefruit juice if you're taking the newer anticoagulants rivaroxaban , dabigatran , apixaban or edoxaban.
Antiplatelet medicines prevent platelets a type of blood cell from sticking together and forming blood clots. However, its ability to treat blood clots was not affected Contrarily, grapefruit increases the blood levels of other medications on this list, which can result in bleeding Alternatives: Warfarin Coumadin is used for purposes similar to those of apixaban and rivaroxaban.
While warfarin is sensitive to foods containing vitamin K, its activation is not affected by grapefruit Several blood thinners are affected by grapefruit. This can lead to bleeding or less effective prevention of blood clots. Fentanyl and oxycodone are narcotic pain relievers. Although their blood levels are only slightly affected by small amounts of grapefruit, it may change the length of time they remain in the body 16 , Colchicine is an older medication used to treat gout.
Nevertheless, a study showed that drinking mL of grapefruit juice only had a minimal effect on its levels Alternatives: Morphine and Dilaudid are narcotic pain relievers that are not affected by grapefruit 1. A few erectile dysfunction and prostate medications deserve attention regarding grapefruit interactions:. Erectile dysfunction medications like sildenafil and tadalafil work by relaxing blood vessels, which increases blood flow to an erection. Because other blood vessels relax with these medications as well, increased blood levels of these drugs caused by grapefruit can decrease blood pressure 8.
Moreover, prostate enlargement medications such as tamsulosin can also cause increased dizziness and low blood pressure when taken with grapefruit Alternatives: Another class of prostate enlargement medications, which includes finasteride and dutasteride, is not significantly affected by grapefruit Grapefruit should not be consumed with erectile dysfunction medications or certain prostate enlargement medications.
Additionally, Rxlist. And some of these medications may have serious side effects when they interact with grapefruit. If you are currently taking medications with grapefruit interactions, switch to an alternative drug or stop consuming grapefruit. Even small amounts of grapefruit can interact with some medications and cause serious side effects.
Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications. Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects. With some drugs, with even small amounts of grapefruit can cause severe side effects.
Therefore, the combination should be avoided. Make sure your doctor and pharmacist know if you regularly consume grapefruit. Grapefruit can affect how fast some drugs — like statins — are absorbed into the bloodstream. Grapefruit juice and grapefruit can affect the way your medicines work, and that food and drug interaction can be a concern. The U. Food and Drug Administration has required that some prescription and over-the-counter OTC drugs generally taken by mouth include warnings against drinking grapefruit juice or eating grapefruit while taking the drug.
Here are examples of some types of drugs that grapefruit juice can cause problems interact with:. Grapefruit juice does not affect all the drugs in the categories above. The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. As a result, the medication may stay in your body for too short or too long a time.
A medication that's broken down too quickly won't have time to work. On the other hand, a medication that stays in the body too long may build up to potentially dangerous levels. The list of medications that can interact with grapefruit includes commonly prescribed medications that:. Another potential problem is that some foods and drinks may contain grapefruit but don't say so in the name or on the ingredients list. For example, numerous citrus-flavored soft drinks contain grapefruit juice or grapefruit extract.
Play it safe with prescription drugs. Always ask your doctor or pharmacist when you get a new prescription if it interacts with any foods or other medicines. If the answer is yes, ask whether you need to eliminate that food from your diet. Katherine Zeratsky, R. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.
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